9ème congrès de la Société Francophone de Thérapie Cellulaire et Génique Paris, 13-15 Juin 2010

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SUNDAY JUNE 13
13h45	Opening ceremony Chairpersons : Nathalie Cartier and François Lemoine
14h00- 14h45	Special lecture : Thierry HEIDMANN (UMR-8122, IGR, France) Endogenous retroviruses and the placental "syncytins": natural history of reiterated and successful retroviral gene transfers in the course of mammal evolution
14h45- 16h45	Gene therapy for the central nervous system Chairpersons: David Klatzmann and Alberto Epstein Nicole DEGLON (CEA, Fontenay aux roses, France) Pre-clinical studies of neurodegenerative diseases Stéphane PALFI (Hôpital H. Mondor / Créteil, I2BM CEA/ Inserm, France) Gene therapy in Parkinson disease: from pre-clinical studies in primates to phase I/II clinical trials. Selected oral presentations Françoise Piguet (INSERM U745, Paris, France) Brain gene therapy for metachromatic leucodystrophy: towards clinical trial. Michel Pohl (INSERM UMRS 975, CRicm, Paris, France) Targeted gene-based strategies for control of spinal cord glial signaling pathways : impact on local neuroinflammation and pathological pain.
16h45- 17h15	Coffee break
17h15- 19h15	David FINK (Dpt of Neurology, University of Michigan, USA) A phase I clinical trial of gene transfer for the treatment of intractable pain Patrick AUBOURG (UMR-745, Hôpital St Vincent de Paul, Paris) Gene therapy in adrenoleukodystrophy Selected oral presentations Elodie Mutel (INSERM U855-Université Lyon 1, Nutrition et Cerveau, Faculté de Médecine Laennec, Lyon, France) Prevention of the development of glycogen storage disease in a mouse model of liver-specific deletion of glucose-6 phosphatase, by in vivo lentiviral gene therapy Sébastien Boni (INSERM U948, Biothérapies hépatiques, CHU Hôtel-Dieu, Nantes, France) Optimization of Integration-Defective Lentiviral Vectors production and sustained production of erythropoietin after lentiviral administration to the liver Anna Buj Bello (Généthon, Evry, France) Muscle-specific expression of myotubularin corrects the phenotype of targeted muscles in mouse models of X-linked myotubular myopathy
19h15-21h00	Poster session (viewing) & welcome reception *Posters will stay exposed for the whole meeting duration*

MONDAY JUNE 14
8h30-10h45	Non-viral Gene Therapy Session Chairpersons: Patrick Midoux and Daniel Scherman Erina A LEVASHINA (UMR-963, IBMC, Strasbourg) Functional dissection of mosquito immune responses by RNAi - opportunities and limitations Gilles DIVITA (UMR-5237, Centre de Recherches de Biochimie Macromoléculaire, Montpellier) Peptide-based nanoparticles for in vivo delivery of siRNA Virginie ESCRIOU (UMR-8151, Inserm U1022, Fac pharma, Paris) Efficient lipoplexes for administration of siRNA Selected oral presentations Fanny Beilvert (INSERM U915, Nantes, France) Modulation of gene expression in the lung using ARN interference Flavie Sicard (INSERM U858, Institut de Médecine Moléculaire de Rangueil, Toulouse, France) Targeting oncogenic microRNAs using lentiviral vectors for the gene therapy of pancreatic cancer. Céline Bouquet (BioAlliance Pharma, Paris, France) Plasmid AMEP, a new efficient and well tolerated antitumor gene product for metastatic melanoma treatment.
10h45-11h15	Coffee Break
11h15-13h00	Vaccinology – Immunotherapy – Infectious diseases Chairpersons: Olivier Boyer and Anne Galy Laurent FISCHER Merial, Lyon Powerful cellular immunity to two sand fly salivary proteins in dogs: could this set the stage for a superior anti-Leishmania vaccine? Wei- Zen WEI (Wayne State University, Detroit, MI, USA) DNA vaccines in cancer therapy Selected oral presentations Maxime Ferrand (INSERM UMR951, Molecular Immunology and Biotherapies, Genethon, Evry, France) Control of the anti-transgene immune responses with miRNA142.3p-regulated rAAV2/1 vectors is not as efficient in dystrophic as in normal mice Anastasia Lanzi (CNRS UMR 8203, Institut Gustave Roussy, Université Paris-Sud, Villejuif, France) Pre-existing anti-adenovirus immune responses control the efficacy of vaccines based on epitope display on adenovirus capsid Ruddy Montandon (CNRS UMR8147, Université Paris Descartes, Faculté de Médecine Site Necker, 161 rue de Sèvres, 75015 Paris, France) Regulatory pro-B cell progenitors for cell therapy of type 1 diabetes
13h00- 15h00	LUNCH
	POSTER SESSION I
15h00-16h00	General Assembly of SFTCG THERMO FISHER SCIENTIFIC award
16h00-18h30	Cell Therapy Session Chairpersons: Michel Pucéat and Anne Weber Yann BARRANDON (EPL, Lausanne, Suisse) Regenerative medicine at the single cell level Sébastien MAURY (UMR-7087, Hôpital de la Salpêtrière, Paris) CD4+CD25+ regulatory T-cell depletion improves the graft-versus-tumor effect of donor lymphocytes after allogeneic hematopoietic stem cell transplantation François PATTOU (U857, CHR de Lille) Cell therapy for diabetEs: Where ? Christine BALDESCHI (INSERM/UEVE U-861, I-STEM, AFM, Evry, France) Human embryonic stem-cell derivatives for full reconstruction of the pluristratified epidermis: a preclinical study Selected oral presentations Ali Ayouaz (INSERM U935, Plate forme cellules souches, Villejuif, France) Following telomeres after cell reprogramming and differentiation of iPS cells Sébastien Corbineau (INSERM U972, IFR93, Université Paris Sud, Hôpital de Bicêtre Le Kremlin-Bicêtre, France) Modelling Familial Hypercholesterolemia by hepatic differentiation of patient specific hiPS cells. Daniel Skuk (Unité de recherche en Génétique humaine, Centre Hospitalier de l'Université Laval, Quebec, QC, G1V 4G2, Canada) Intramuscular transplantation of human postnatal myoblasts in immunodeficient mice produces functional graft-derived satellite cells.

TUESDAY JUNE 15
	Special thematic session: “Targeted integration, epigenetic and chromatin regulation”
8h30-10h15	Homologous Recombination Chairpersons: Olivier Danos and Nicolas Ferry Toni CATHOMEN, Hannover Medical School, Hannover, Germany Targeted genome modifications: Zinc positive Frédéric PAQUES (Cellectis, Romainville) Meganucleases and gene therapy: different strategies Selected oral presentations Adrien Léger (INSERM UMR649, Institut de Recherche Thérapeutique, Nantes, France) The Rous Sarcoma Virus promoter carried by a rAAV vector is resistant to DNA methylation in primate muscle and liver Guillaume Corre (INSERM UMR951, Ecole Pratique des Hautes Etudes, UEVE, Généthon, Evry, France) Stochastic epigenetic fluctuations of transgene expression Andras Paldi (INSERM UMR951, Ecole Pratique des Hautes Etudes, UEVE, Généthon, Evry, France) Epigenetic changes induced in human hematopoietic progenitor/stem cells following ex vivo lentiviral transduction
10h15-10h45	Coffee Break
10h45-11h45	Homologous Recombination: applications Angelo LOMBARDO (Tiget, Milano, Italy) Combining Site-Specific Integration and Cassette Design to Achieve Robust Expression without Impacting Endogenous Gene Expression Ignacio ANEGON (UMR-643, Nantes, France) Zinc-finger nucleases: a powerful tool for genetic engineering of animals
11h45-13h00	POSTER SESSION II
13h00-14h00	LUNCH
14h00-15h30	Epigenetics, chromatin and nuclear organization Chairpersons: Claire Rougeulle and Anna Salvetti Carmelo FERRAI (MRC Clinical Sciences Centre, Imperial College London, UK) Gene regulation: from chromatin structure to nuclear compartmentalization Claire FRANCASTEL (UMR 7216, Université Paris Diderot, Paris) Chromatin marks and subnuclear positioning at lineage-affiliated genetic programs to predict differentiation potential of multipotent hematopoietic progenitors Manuel GREZ (Institute for Biomedical Research, Frankfurt, Germany) A lentiviral vector for the correction of Chronic Granulomatous Disease containing a chromatin opening element provides copy-dependent expression and resistance to CpG methylation.
15h30-16h00	Best oral presentation and best poster awards
	Closure