INV15
Retinal pigment epithelial cells derived from human embryonic stem cells disposed on human amniotic membrane: an update on the french rp clinical trial
C Monville ¹ ² S Bertin ³ E Brazhnikova ⁴ C Labetoule ¹⁰ S Abbas ¹ ⁵ C Jaillard ⁴ W Habeler ¹ ⁵ A Plancheron ¹ ⁵ C Fovel ⁶ J Demilly ⁶ M Jarraya ⁷ A Bejanariu ¹ ⁵ T Bordet ⁸ I Audo ³ ⁴ M Pâques ³ J A Sahel ³ ⁴ ⁹ M Peschanski ¹ ⁵ O Goureau ⁴ K Ben M’Barek ¹ ⁵
1: INSERM U861, I-Stem, AFM, Institute for Stem cell Therapy and Exploration of Monogenic diseases, 91100 Corbeil-Essonnes, France; 2: Université Paris-Saclay, Université d’Evry, 91100 Corbeil-Essonnes, France 3: CHNO des Quinze-Vingts, DHU Sight Restore, INSERM-DGOS CIC 1423, Paris, France ; 4: Institut de la Vision, INSERM U968, Sorbonne Universités, UPMC Univ Paris 06, UMR_S968 ; CNRS, UMR_7210, Paris, France ; 5: Centre d’Etude des Cellules Souches, 91100 Corbeil-Essonnes, France 6: CEA-MIRCen, 92260 FAR, France ; 7: Banque de Tissus humains, Hôpital Saint Louis, AP-HP, Paris, France ; 8: EyeVensis, Paris, France 9: Department of Ophtalmology, University of Pittsburg School of medicine, Pittsburg, PA 15213, USA 10: Genethon, Institut des Biothérapies, 91100 Corbeil-Essonnes, France
In developed countries, retinal degenerative diseases affecting Retinal Pigmented Epithelium (RPE), including Age-related Macular Dystrophy and inherited retinal diseases such as Retinitis Pigmentosa (RP), are the predominant causes of human blindness worldwide. Despite the scientific advances achieved in the last years, there is no cure for such diseases. In this context, we have developed a cell therapy medicinal product based on our expertise in tissue engineering and in the manipulation of pluripotent stem cells. This novel tissue engineered product (TEP) consists in RPE cells derived from clinical grade human embryonic stem cells disposed on a biocompatible substrate allowing the formation of a 3D functional sheet, suitable for transplantation. After functional validation in a rodent model of RP (Ben M'Barek et al., 2017), our purpose was to test the safety of the surgery and local tolerance in non-human primates (NHP).