PROGRAMME
Thursday 21 March: SFTCG Academy
This Academy-type programme, including one mentoring talk, will give 8 students the opportunity to present their work on any topic as long as it falls under the gene and cell therapy umbrella. This event is free of charge for SFTCG student members and can either be attended on its own or combined with the Theme Day to be held on 22 March.
Students can submit an abstract for this Academy day on any topic as long as it is gene and cell therapy related. We will select the top 8 abstracts submitted regardless of the categories. Of course abstracts in gene editing or cell therapy are more likely to be selected for the Theme Day rather than for the Academy.
12:00-13:00
Registration and light lunch
13.00-14.00
Mentoring
Chair: Els Verhoeyen
INV01 Zoltan Ivics, Paul Ehrlich Insitute, Langen
Digging in the Dirt: How Archeogenetics and Synthetic Biology Impacted Gene Therapy
14.00-15.30 (10 minutes presentation and 20 minutes for questions and mentoring)
Oral presentations from students
Chairs: Sophie Gomez, Capucine Trollet, Els Verhoeyen
OR01 Clémence Lièvre, TaRGeT, Nantes
Skeletal muscle organoids for preclinical gene therapy with recombinant AAV vectors
OR02 Clément Morival, TaRGeT, Nantes
Modelling Stargardt disease using three-dimensional retinal organoids
OR03 Carine Bourdais, IRBM, Montpellier
Combined cellular and gene therapy to treat primary ciliary dyskinesia.
15:30-16:00
Coffee Break
16.00-18.00 (10 minutes presentation and 20 minutes for questions and mentoring)
Oral presentations from students
Chairs: Olivier Négre, Françoise Piguet
OR05 Manon Lucas, TaRGeT, Nantes
High systemic dosing of AAV9 vectors: a relevant rat model to study the impact of vector immunogenicity in the liver
OR06 Laurie Lacombe, Généthon Evry
NHEJ inhibition increases homology-mediated AAV integration in hematopoietic cells
OR07 Jean Baptiste Ducloyer, TaRGeT, Nantes
Study of retinal microglial cells after sub-retinal injection of recombinant AAV in pigs
OR08 Marie Esnard, GEPEA – St Nazaire / TaRGeT, Nantes
Development of an AAV bioproduction technological platform in microalgae
Friday 22 March: Theme Day
THEMATIC MORNING ON GENE EDITING
08:00-09:00
Registration
09.00-10.30
(10 minutes presentation and 5 minutes for questions)
Session 1
Chair: François Moreau Gaudry, Caroline Le Guiner
INV02 Carine Giovannangeli,
INV03 Annarita Miccio, Institut Imagine
Genome editing approaches for hematopoietic disorders
OR09 Paloma Navas Navarro, Généthon Evry
Treatment of myotonic dystrophy type 1 with CRISPR/Cas9
OR10 Margaux Melka, Institut des Neurosciences de Grenoble
Mutation independent CRISPR/Cas9-induced allele deletion results in vitro in a functional benefit for dominant RYR1 mutation
10:30-11:00
Coffee Break
11.00-12.30
(10 minutes presentation and 5 minutes for questions)
Session 2
Chair: Mario Amendola, Matthias Titeux
INV04 Maria Silvia Roman Azcona , University of Freiburg
Epigenome editing of immune checkpoints in CAR T cells
INV05 François Moreau Gaudry, University of Bordeaux
Genotoxicity risk induced by CRISPR-Cas9: understanding and preventing i
OR11 Juliette Varin,TaRGeT, Nantes
Homology-independent targeted integration (HITI) as possible treatment for Stargardt disease
OR12 Hugo Malki, Institut de la Vision, Paris
Delivery of Cas9 ribonucleoprotein to the retina of mice with Retinitis pigmentosa
12:30-14:00
Lunch
THEMATIC AFTERNOON ON CELL THERAPY
14.00-15.30 (10 minutes presentation and 5 minutes for questions)
Session 3
Chair: Christelle Monville, Leila Maouche Chrétien
INV08 Philippe Menasché, Université Paris Cité.
Cell therapy for cardiac diseases: sucesses and remaining challenges
INV09 Karl Rouger, PanTher - INRAe, ONIRIS, UMR 703 - Nantes
Muscle repair potential of adult stem cells through different modes of action
OR13 Isabelle Prost, Promega, France
New technologies for CAR-T characterization and potency testing
OR14 Allwyn Pereira, TaRGeT, Nantes
Multiomic analyses reveals epigenome remodeling and transcriptional co-factors as critical determinants for neuronal cell therapy
15:30-16:00
Coffee Break
16.00-17.30 (10 minutes presentation and 5 minutes for questions)
Session 4
Chair: Oumeya Adjali, Emmanuel Payen
INV11 Jérémie Martinet, Rouen University
Irradiation as an adjuvant for CAR-T cell therapy
INV12 Vasco Meneghini, Hospital San Raffaele, Milano
Tackling neurodegeneration with neural stem and progenitor cells
OR15 Camille Le Guen, CHU Nantes
Can academic structures improve access to CAR-T cells?
Closing